Wideband Handheld Confocal Raman Skin Analyzer--Simscop Instrument (Guangzhou) Co., Ltd

Product Overview
Specifications
Applications
Q&A

Wideband Handheld Confocal Raman Skin Analyzer

DermDive

Confocal Raman spectroscopy (CRS) is a breakthrough optical technology widely used in biological tissue analysis and is praised for its non-invasive method, precise localization and comprehensive biochemical insights. Although traditional CRS systems have limitations in detection capabilities, bulky design, insufficient flexibility, slow data collection, and rising costs, DermDive, as a new type of equipment, aims to overcome these challenges and provide more efficient, Portable and cost-effective skin analysis solutions.

Key Advantage

A harmonized integration of single or dual-wavelength lasers through an efficient (>90%) wavelength combiner, enabling near-instantaneous excitation.
The groundbreaking Raman Spectra Separation Algorithm (PRSSA), a pioneer in spectrum separation, harnessing the maximum a posteriori probability (MAP) estimate.
A notable reduction in data collection time, outpacing conventional CRS systems by over 50%.

Product Brochure

Wideband Handheld Confocal Raman Skin Analyzer

DermDive

Key Advantage

A harmonized integration of single or dual-wavelength lasers through an efficient (>90%) wavelength combiner, enabling near-instantaneous excitation.
The groundbreaking Raman Spectra Separation Algorithm (PRSSA), a pioneer in spectrum separation, harnessing the maximum a posteriori probability (MAP) estimate.
A notable reduction in data collection time, outpacing conventional CRS systems by over 50%.

Product Brochure

Confocal Raman Spectroscopy (CRS) is a groundbreaking optical technology used extensively for biological tissue analysis, prized for its noninvasive approach, pinpoint accuracy and comprehensive biochemical insights. Despite its advantages, traditional CRS systems are encumbered by limited detection, cumbersome designs, reduced flexibility, slow data collection, and escalated costs.

To counter these challenges, we are developed a compact, handheld CRS system, aptly named “DermDive”. DermDive is the world first wideband handheld confocal Raman skin analyzer covering both finger-print region (FP, 450–1750 cm–1) and high wavenumber region (HW, 2800–3800 cm–1) with a handheld probe. DermDive has adjustable and user-defined measurement time suitable for various applications. It provides molecular information at different skin layers noninvasively, up to 200.

DermDive is designed to be user-friendly for skin diagnosis on various parts of human body, thanks to its flexibility.

Features

A harmonized integration of single or dual-wavelength lasers through an efficient (>90%) wavelength combiner, enabling near-instantaneous excitation.
The groundbreaking Raman Spectra Separation Algorithm (PRSSA), a pioneer in spectrum separation, harnessing the maximum a posteriori probability (MAP) estimate. This offers an astounding >99% accuracy, as evidenced in both laboratory simulations and real-time human skin analyses.
A notable reduction in data collection time, outpacing conventional CRS systems by over 50%.

√ Noninvasive √ Depth profiling

√ Fast √ Safe

√ User friendly √ Fingerprint region + high wavenumber region

√ Handheld

Light Path Diagram

Available Raman Spectra Database

Natural moisturizing factors (NMF), water, ceramide, keratin, lactic acid, urea, urocanic acid at different depths.

Software's UI & Function

Parameter	DermDive
Detection Range	FP: 450 – 1750cm-1; HW: 2800-3750cm-1
Axial Resolution	10um~20um
Sensitivity	60dB
Scanning Time	2-10s/depth
Probe Size	~12 cm × 6 cm × 5 cm
Probe Weight	~800g
Device Size	~ H: 1m, W: 50cm, L: 50cm
Device Weight	~ 40kg

Benchmarking with RiverD Benchtop CRS

Spectra of DermDive and RiverD at single depth and Various depths. Spectra qualities are comparable.

Optical Performance Characterization

Axial resolutions and sensitivities with different optical components.

1. What is Raman spectroscopy? What are the differences between Rayleigh, Stokes Raman, and Anti-Stokes Raman scattering?

For a detailed analysis, please refer to the provided article link.

2. Can you elaborate on Confocal Raman Spectroscopy?

Confocal Raman Spectroscopy (CRS) is an advanced analytical method that merges the principles of Raman spectroscopy and confocal microscopy. It utilizes the Raman effect, where light interaction with molecules causes a frequency shift, providing insights into molecular vibrations and chemical structures. The confocal aspect enhances spatial resolution by focusing light through a small aperture, improving image clarity and reducing background noise.

CRS is particularly effective for detailed analysis of materials at the microscale, allowing for high-resolution chemical imaging in both lateral and depth dimensions. This non-invasive technique is valuable in fields requiring sample integrity, such as biomedical research and art authentication. It finds diverse applications in chemistry, physics, biomedical sciences, and materials science, enabling detailed studies of cellular drug distribution, art pigment composition, and structural characteristics of advanced materials. The technique's non-destructive nature and minimal sample preparation requirements make it a preferred choice for analyzing complex samples.